Sunday Symposium

Welcome to the Centre Universitaire Méditerranéen (CUM) hosting the CinC-2015 Sunday Symposium on Sept 6.

For this new edition, the symposium will take place in one of the most beautiful French amphitheaters, located at CUM, right on the world-famous Promenade des Anglais

Address: Centre Universitaire Méditerranéen, 65 Promenade des Anglais, 06000 Nice
Bus lines: 3, 8, 9, 10, 12, 22, 23, 11 ("Grosso CUM Promenade" stop)
No tram

More information for coming from the airport or from the town here


The topic of this year's symposium will be "Multiscale Computing in Cardiology", where five exciting talks by renowned experts in the field will look at the heart from different perspectives, ranging from cell level to cardiac pathology and interaction with other organs.

The tentative program will be as follows: 

  • 13h00-13h45: Registration

  • 13h45-14h00: Opening remarks

  • 14h00-14h45: Pr. J. Barhanin, LP2M - UMR CNRS-UNS 7370, Faculty of Medicine, University of Nice Sophia Antipolis, France
"Roles of cardiac potassium channels in repolarization and arrhythmia" 
Potassium channels form a very diverse class of ion channels that generate K+ currents crucial for modulation of membrane potential in almost all living cells. In the heart, these channels are responsible for the repolarizing currents controlling the action potential frequency and duration. K+ channels form a so-called repolarization reserve that allows maintaining the stability of heart beating in all conditions. Mutations in genes encoding cardiac K+ currents have been associated with a number of idiopathic ventricular and supraventricular arrhythmias such as long and short QT syndromes and atrial fibrillation.
After a short review of the different class of K+ channels expressed in cardiac cells, some example of their implications in inherited arrhythmic disorders will be discussed.
  • 14h45-15h30: Dr. J. Jeremy Rice, Computational Biology Center, IBM T.J. Watson Research Center, USA
"Applications requiring high-resolution electrical and mechanical heart models" 
Limited compute power has mostly restricted electrophysiological heart models to spatial discretizations that are much coarser than heart cells.  Here, we remove the compute limitation by running on Lawrence Livermore National Laboratory’s Sequoia, a 96-rack Blue Gene Q computer with a peak speed of 20 PFLOPS.  A two ventricle model of the human heart with a spatial discretization of 0.1 mm, roughly the long dimension of a heart cell, can be simulated in just over 3 seconds, more than three orders of magnitude faster than previous benchmarks.  In mechanics, spatial resolution has been constrained primarily by theoretical and algorithm limitations.  We present a new approach in which deformation of the ventricles is solved using an iterative solver for an ill-conditioned system of equations derived from an implicit numerical method. For the first time, ventricular geometries with trabeculae and papillary muscles can be simulated, and the dispersion of transmural strains predicted across the ventricular wall is similar to real measures.
  • 15h30-16h00: Coffee break

  • 16h00-16h45: Dr. G. Latcu, Cardiology Service, Princess Grace Hospital Center, Monaco
"How and when can we manage atrial fibrillation with catheter ablation techniques?"
Catheter ablation of atrial fibrillation, performed since more than 15 years, has reached maturity and is continuously improving. Technological advancements and conceptual novelties are constantly changing it. Since 2012, indications for management of atrial fibrillation with catheter ablation were upgraded and their level of evidence was improved. It concerns virtually any symptomatic patient with paroxysmal atrial fibrillation and may be performed in many patients with persistent forms. Debate is now ongoing whether the actual results can be furthermore improved, but an earlier treatment, a better patient selection and a better definition of the targets to be ablated give hope for further improvement.
  • 16h45-17h30: Pr. M. Sermesant, Asclepios Project, INRIA, France
"Integration of electrophysiology and imaging for patient-specific models and intervention planning"
In this talk, I will present how the advances in medical imaging and biophysical modelling allow to adjust electromechanical models of the myocardium to clinical data. Such patient-specific models can then be used to simulate the effect of interventions, in order to help therapy planning.This will be illustrated on ventricular tachycardia and heart failure.
  • 17h30-18h15: Pr. M. Amann, Department of Internal Medicine, University of Utah, USA
"Neural circulation control during exercise: impact of aging and heart failure"
Group III/IV muscle afferents play a significant role in regulating the cardiovascular and hemodynamic response to physical activities. Specifically, these sensory neurons modulate various autonomic responses to exercise and thereby assure adequate muscle blood flow and oxygen delivery. Although aging has no effect on the contribution of group III/IV muscle afferents in regulating arterial blood pressure during exercise (i.e. the so-called exercise pressor reflex), the mechanisms accounting for this response are altered in the elderly. While young individuals predominantly rely on alterations in cardiac output to change arterial blood pressure, the role of the heart decreases with age and peripheral vasomotor activation becomes a more prominent mechanism in determining the exercise pressor reflex in the elderly. Additionally, although group III/IV muscle afferents play a clear role in increasing leg vascular conductance during locomotor exercise in the young, it seems that these afferents may actually compromise exercise-induced peripheral hemodynamics in older individuals. Heart failure further impairs the neural control of the circulation. Specifically, although group III/IV muscle afferents remain an important determinant for central hemodynamics in patients with heart failure, it also appears that these sensory neurons cause excessive sympatho-excitation impairing limb blood flow which likely contributes to the exercise intolerance in this population. This presentation will highlight key human findings documenting the influence of group III/IV muscle afferents in the circulatory response to physical activities and focus on the impact of healthy aging and heart failure on this regulatory mechanism. 
  • ​18h15-18h45: Closing remarks and discussion

  • 19h00-21h00: Reception at CUM.